Difficulties are different settings that adjust the games overall experience. Players who are new to Dungeon Defenders should play through the campaign on easy then work their way up. Easy difficulty is going to have low health, low damage doing, and low spawning amount creatures. And oppositely Nightmare is going to have the highest health, highest damage dealing, and highest amount of spawned creatures. On top of changing creature strengths and combatant skills, difficulties also change loot dropped and awarded. The higher difficulty played the better Armor, Weapons, and Familiars the player will receive.
|Nightmare (PC Only)|
|Insane+ (Console Only)|
NOTE: The Nightmare difficulty is not available in the console versions of Dungeon Defenders. Additionally, the Insane+ difficulty is not available in the PC version of the game.